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In Chapter 12 of Tom Sawyer, Aunt Polly is trying a series of remedies and medicines to cure Tom from his condition. I don't think Tom is REALLY sick, he is just depressed and with low energies. He got sick psycologically after finding out that Becky was very sick and stopped attending school. Aunt Pollys remedies are from a subscription that have "cures" that consist on excercise and food diets, what to wear, and several other things he has to do. These "cures" change every month, so they are either superticious or made up by someone. Besides, if the cures DID work, they would have an effect on Tom, because he is only feeling depression. I think it is realistic to feel sick if one is feeling depressed or mad, it is a matter of how your brain works psycologically. Also, I think the painkiller DID have an effect on Tom because it is a really strong medicine that has a noticeable effect on people.